Regulation of the noradrenaline neurotransmitter phenotype by the transcription factor AP-2β
نویسندگان
چکیده
From the Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, the Department of Neurology and Neurobiology, Pharmacology & Physiology, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL 60637, and the Institute of Pathology, University Hospital Bonn, Sigmund-Freud-Str. 25, D-53127, Bonn, Germany. Present address: Department of Medicinal Herbology, 312 College of Pharmacy, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea
منابع مشابه
1 Regulation of the noradrenaline neurotransmitter phenotype by the transcription factor AP - 2 β
From the Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, the Department of Neurology and Neurobiology, Pharmacology & Physiology, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL 60637, and the Institute of Pathology, University Hospital Bonn, Sigmund-Freud-Str. 25, D-53127, Bonn, Germany. Present address: Department of ...
متن کاملPostprandial activation of protein kinase Cµ regulates the expression of adipocytokines via the transcription factor AP-2β.
Abnormal secretion of adipocytokines promotes atherosclerosis, diabetes and insulin resistance, and is mainly induced by adipocyte hypertrophy. Recently, the circulating adipocytokine concentrations were reported to change in the postprandial period, as the levels of TNFα, IL-6 IL-8 and MCP-1 increased after a meal, whereas that of adiponectin decreased. These data suggest that prandial modulat...
متن کاملAP-2β Is a Downstream Effector of PITX2 Required to Specify Endothelium and Establish Angiogenic Privilege During Corneal Development
PURPOSE The homeodomain transcription factor, PITX2, is at the apex of a genetic pathway required for corneal development, but the critical effector genes regulated by the PITX2 remain unknown. The purpose of this study was to discover and validate PITX2-dependent mechanisms required for specifying cell lineages and establishing angiogenic privilege within the developing cornea. METHODS Micro...
متن کاملGAS41 interacts with transcription factor AP-2β and stimulates AP-2β-mediated transactivation
Transcription factor AP-2 regulates transcription of a number of genes involving mammalian development, differentiation and carcinogenesis. Recent studies have shown that interaction partners can modulate the transcriptional activity of AP-2 over the downstream targets. In this study, we reported the identification of GAS41 as an interaction partner of AP-2beta. We documented the interaction bo...
متن کاملConditional deletion of AP-2β in mouse cranial neural crest results in anterior segment dysgenesis and early-onset glaucoma
Anterior segment dysgenesis (ASD) encompasses a group of developmental disorders in which a closed angle phenotype in the anterior chamber of the eye can occur and 50% of patients develop glaucoma. Many ASDs are thought to involve an inappropriate patterning and migration of the periocular mesenchyme (POM), which is derived from cranial neural crest cells (NCCs) and mesoderm. Although, the mech...
متن کامل